IUBMB Enzyme Nomenclature

EC 1.14.13.9

Accepted name: kynurenine 3-monooxygenase

Reaction: L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O

For diagram of reaction click here.

Other name(s): kynurenine 3-hydroxylase; kynurenine hydroxylase; L-kynurenine-3-hydroxylase

Systematic name: L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)

Comments: A flavoprotein (FAD). Formerly EC 1.14.1.2 and EC 1.99.1.5.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9029-61-2

References:

1. de Castro, F.T., Price, J.M. and Brown, R.R. Reduced triphosphopyridinenucleotide requirement for the enzymatic formation of 3-hydroxykynurenine from L-kynurenine. J. Am. Chem. Soc. 78 (1956) 2904-2905.

2. Okamoto, H. and Hayaishi, O. Flavin adenine dinucleotide requirement for kynurenine hydroxylase of rat liver mitochondria. Biochem. Biophys. Res. Commun. 29 (1967) 394-399. [PMID: 6076241]

3. Saito, Y., Hayaishi, O. and Rothberg, S. Studies on oxygenases: enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine. J. Biol. Chem. 229 (1957) 921-934.

[EC 1.14.13.9 created 1961 as EC 1.99.1.5, transferred 1965 to EC 1.14.1.2, transferred 1972 to EC 1.14.13.9]


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