Reaction: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O
Other name(s): microsomal monooxygenase; xenobiotic monooxygenase; aryl-4-monooxygenase; aryl hydrocarbon hydroxylase; microsomal P-450; flavoprotein-linked monooxygenase; flavoprotein monooxygenase
Systematic name: substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
Comments: A group of heme-thiolate proteins (P-450), acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. Together with EC 126.96.36.199 NADPHhemoprotein reductase, it forms a system in which two reducing equivalents are supplied by NADPH. Formerly EC 188.8.131.52, EC 184.108.40.206 and EC 220.127.116.11. Some of the reactions attributed to EC 18.104.22.168 (alkane 1-monooxygenase) belong here.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 62213-32-5
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