IUBMB Enzyme Nomenclature

EC 1.14.15.4

Accepted name: steroid 11β-monooxygenase

Reaction: a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11β-hydroxysteroid + 2 oxidized adrenodoxin + H2O

Other name(s): steroid 11β-hydroxylase; steroid 11β/18-hydroxylase

Systematic name: steroid,reduced-adrenodoxin:oxygen oxidoreductase (11β-hydroxylating)

Comments: A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9029-66-7

References:

1. Grant, J.K. and Brownie, A.C. The role of fumarate and TPN in steroid enzymic 11β-hydroxylation. Biochim. Biophys. Acta 18 (1955) 433-434. [PMID: 13276417]

2. Hayano, M. and Dorfman, R.I. On the mechanism of the C-11β-hydroxylation of steroids. J. Biol. Chem. 211 (1954) 227-235. [PMID: 13211659]

3. Tomkins, G.M., Michael, P.J. and Curran, J.F. Studies on the nature of steroid 11β-hydroxylation. Biochim. Biophys. Acta 23 (1957) 655-656. [PMID: 13426185]

4. Yanagibashi, K., Haniu, M., Shively, J.E., Shen, W.H. and Hall, P. The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11β-, 18-hydroxylation, and aldehyde synthesis. J. Biol. Chem. 261 (1986) 3556-3562. [PMID: 3485096]

5. Zuidweg, M.H.J. Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata. Biochim. Biophys. Acta 152 (1968) 144-158. [PMID: 4967077]

[EC 1.14.15.4 created 1961 as EC 1.99.1.7, transferred 1965 to EC 1.14.1.6, transferred 1972 to EC 1.14.15.4, modified 1989, modified 2014]


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