Reaction: a steroid + reduced adrenodoxin + O2 = an 11β-hydroxysteroid + oxidized adrenodoxin + H2O
Other name(s): steroid 11β-hydroxylase; steroid 11β/18-hydroxylase
Systematic name: steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11β-hydroxylating)
Comments: A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone. Formerly EC 220.127.116.11 and EC 18.104.22.168.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9029-66-7
1. Grant, J.K. and Brownie, A.C. The role of fumarate and TPN in steroid enzymic 11β-hydroxylation. Biochim. Biophys. Acta 18 (1955) 433-434.
2. Hayano, M. and Dorfman, R.I. On the mechanism of the C-11β-hydroxylation of steroids. J. Biol. Chem. 211 (1954) 227-235.
3. Tomkins, G.M., Michael, P.J. and Curran, J.F. Studies on the nature of steroid 11-β hydroxylation. Biochim. Biophys. Acta 23 (1957) 655-656.
4. Yanagibashi, K., Haniu, M., Shively, J.E., Shen, W.H. and Hall, P. The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11β-, 18-hydroxylation, and aldehyde synthesis. J. Biol. Chem. 261 (1986) 3556-3562. [PMID: 3485096]
5. Zuidweg, M.H.J. Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata. Biochim. Biophys. Acta 152 (1968) 144-158. [PMID: 4967077]