Reaction: dopamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O
For diagram click here.
Glossary: dopamine = 4-(2-aminoethyl)benzene-1,2-diol
Other name(s): dopamine β-hydroxylase; MDBH (membrane-associated dopamine β-monooxygenase); SDBH (soluble dopamine β-monooxygenase); dopamine-B-hydroxylase; oxygenase, dopamine β-mono-; 3,4-dihydroxyphenethylamine β-oxidase; 4-(2-aminoethyl)pyrocatechol β-oxidase; dopa β-hydroxylase; dopamine β-oxidase; dopamine hydroxylase; phenylamine β-hydroxylase; (3,4-dihydroxyphenethylamine)β-mono-oxygenase; DβM
Systematic name: 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (β-hydroxylating)
Comments: A copper protein. Stimulated by fumarate. Formerly EC 22.214.171.124.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9013-38-1
1. Friedman, S. and Kaufman, S. 3,4-Dihydroxyphenylethylamine β-hydroxylase. Physical properties, copper content, and role of copper in the catalytic activity. J. Biol. Chem. 240 (1965) 4763-4773. [PMID: 5846992]
2. Levin, E.Y., Levenberg, B. and Kaufman, S. The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine. J. Biol. Chem. 235 (1960) 2080-2086.