IUBMB Enzyme Nomenclature

EC 1.14.17.1

Accepted name: dopamine β-monooxygenase

Reaction: dopamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O

For diagram click here.

Glossary: dopamine = 4-(2-aminoethyl)benzene-1,2-diol

Other name(s): dopamine β-hydroxylase; MDBH (membrane-associated dopamine β-monooxygenase); SDBH (soluble dopamine β-monooxygenase); dopamine-B-hydroxylase; oxygenase, dopamine β-mono-; 3,4-dihydroxyphenethylamine β-oxidase; 4-(2-aminoethyl)pyrocatechol β-oxidase; dopa β-hydroxylase; dopamine β-oxidase; dopamine hydroxylase; phenylamine β-hydroxylase; (3,4-dihydroxyphenethylamine)β-mono-oxygenase; DβM

Systematic name: 3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (β-hydroxylating)

Comments: A copper protein. Stimulated by fumarate. Formerly EC 1.14.2.1.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9013-38-1

References:

1. Friedman, S. and Kaufman, S. 3,4-Dihydroxyphenylethylamine β-hydroxylase. Physical properties, copper content, and role of copper in the catalytic activity. J. Biol. Chem. 240 (1965) 4763-4773. [PMID: 5846992]

2. Levin, E.Y., Levenberg, B. and Kaufman, S. The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine. J. Biol. Chem. 235 (1960) 2080-2086.

[EC 1.14.17.1 created 1965 as EC 1.14.2.1, transferred 1972 to EC 1.14.17.1]


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