Reaction: L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O
Other name(s): tyrosinase; phenolase; monophenol oxidase; cresolase; catechol oxidase; polyphenolase; pyrocatechol oxidase; dopa oxidase; chlorogenic oxidase; catecholase; polyphenol oxidase; monophenolase; o-diphenol oxidase; chlorogenic acid oxidase; diphenol oxidase; o-diphenolase; tyrosine-dopa oxidase; o-diphenol:oxygen oxidoreductase; polyaromatic oxidase; monophenol monooxidase; o-diphenol oxidoreductase; monophenol dihydroxyphenylalanine:oxygen oxidoreductase; N-acetyl-6-hydroxytryptophan oxidase; monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase; o-diphenol:O2 oxidoreductase; phenol oxidase
Systematic name: monophenol,L-dopa:oxygen oxidoreductase
Comments: A group of copper proteins that also catalyse the reaction of EC 1.10.3.1 catechol oxidase, if only 1,2-benzenediols are available as substrate.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 9002-10-2
References:
1. Dawson, C.R. and Tarpley, W.B. The copper oxidases. In: Sumner, J.B. and Myrbäck, K. (Eds.), The Enzymes, 1st ed., vol. 2, Academic Press, New York, 1951, p. 454-598.
2. Lerch, K. Amino acid sequence of tyrosinase from Neurospora crassa. Proc. Natl. Acad. Sci. USA 75 (1978) 3605-3609. [PMID: 151279]
3. Malmström, B.G., Andréasson, L.-E. and Reinhammar, B. Copper-containing oxidases and superoxide dismutase. In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 12, Academic Press, New York, 1975, p. 507-579.
4. McIntyre, R.J. and Vaughan, P.F.T. Kinetic studies on the hydroxylation of p-coumaric acid to caffeic acid by spinach-beet phenolase. Biochem. J. 149 (1975) 447-461. [PMID: 170916]
5. Patil, S.S. and Zucker, M. Potato phenolases. Purification and properties. J. Biol. Chem. 240 (1965) 3938-3943. [PMID: 5842066]
6.Pomerantz, S.H. Separation, purification, and properties of two tyrosinases from hamster melanoma. J. Biol. Chem. 238 (1963) 2351-2357.
7. Robb, D.A. Tyrosinase. In: Lontie, R. (Ed.), Copper Proteins and Copper Enzymes, vol. 2, C.R.C. Press, Boca Raton, FL, 1984, 207-240.