IUBMB Enzyme Nomenclature


Accepted name: methane monooxygenase (particulate)

Reaction: methane + quinol + O2 = methanol + quinone + H2O

Systematic name: methane,quinol:oxygen oxidoreductase

Comments: Contains copper. It is membrane-bound, in contrast to the soluble methane monooxygenase (EC

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Shiemke, A.K., Cook, S.A., Miley, T. and Singleton, P. Detergent solubilization of membrane-bound methane monooxygenase requires plastoquinol analogs as electron donors. Arch. Biochem. Biophys. 321 (1995) 421-428. [PMID: 7646068]

2. Basu, P., Katterle, B., Andersson, K.K. and Dalton, H. The membrane-associated form of methane mono-oxygenase from Methylococcus capsulatus (Bath) is a copper/iron protein. Biochem. J. 369 (2003) 417-427. [PMID: 12379148]

3. Kitmitto, A., Myronova, N., Basu, P. and Dalton, H. Characterization and structural analysis of an active particulate methane monooxygenase trimer from Methylococcus capsulatus (Bath). Biochemistry 44 (2005) 10954-10965. [PMID: 16101279]

4. Balasubramanian, R. and Rosenzweig, A.C. Structural and mechanistic insights into methane oxidation by particulate methane monooxygenase. Acc. Chem. Res. 40 (2007) 573-580. [PMID: 17444606]

[EC created 2011]

Return to EC 1.14.18 home page
Return to EC 1.14 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page