IUBMB Enzyme Nomenclature

EC 1.14.99.11

Accepted name: estradiol 6β-monooxygenase

Reaction: estradiol-17β + AH2 + O2 = 6β-hydroxyestradiol-17β + A + H2O

Other name(s): estradiol 6β-hydroxylase

Systematic name: estradiol-17β,hydrogen-donor:oxygen oxidoreductase (6β-hydroxylating)

Comments: Formerly EC 1.14.1.10 and EC 1.99.1.8.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9029-70-3

References:

1. Haines, W.J. The biosynthesis of adrenal cortex hormones. Recent Progr. Hormone Res. 7 (1952) 255-305.

2. Mueller, G.C. and Rumney, G. Formation of 6β-hydroxy and 6-keto derivatives of estradiol-16-C14 by mouse liver microsomes. J. Am. Chem. Soc. 79 (1957) 1004-1005.

[EC 1.14.99.11 created 1965 as EC 1.14.1.10, transferred 1972 to EC 1.14.99.11]


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