IUBMB Enzyme Nomenclature

EC 1.14.99.29

Accepted name: deoxyhypusine monooxygenase

Reaction: [eIF5A]-deoxyhypusine + AH2 + O2 = [eIF5A]-hypusine + A + H2O

For diagram click here.

Glossary: deoxyhypusine = N6-(4-aminobutyl)-L-lysine
hypusine = N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine

Other name(s): deoxyhypusine hydroxylase; deoxyhypusine dioxygenase

Systematic name: deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)

Comments: The enzyme catalyses the final step in the formation of the amino acid hypusine in the eukaryotic initiation factor 5A.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 101920-83-6

References:

1. Abbruzzese, A., Park, M.H. and Folk, J.E. Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization. J. Biol. Chem. 261 (1986) 3085-3089. [PMID: 3949761]

[EC 1.14.99.29 created 1989]


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