Reaction: a steroid + AH2 + O2 = a 17α-hydroxysteroid + A + H2O
Other name(s): steroid 17α-hydroxylase; cytochrome P-45017α; cytochrome P-450 (P-45017α,lyase); 17α-hydroxylase-C17,20 lyase
Systematic name: steroid,hydrogen-donor:oxygen oxidoreductase (17α-hydroxylating)
Comments: Requires NAD(P)H and P-450. Formerly EC 1.14.1.7 and EC 1.99.1.9.
Links to other databases: BRENDA, EXPASY, KEGG, PDB, CAS registry number: 9029-67-8
References:
1. Lynn, W.S. and Brown, R.H. The conversion of progesterone to androgens by testes. J. Biol. Chem. 232 (1958) 1015-1030.
2. Yoshida, K.-I., Oshima, H. and Troen, P. Studies of the human testis. XIII. Properties of nicotinamide adenine dinucleotide (reduced form)-linked 17α-hydroxylation. J. Clin. Endocrinol. Metab. 50 (1980) 895-899. [PMID: 6966286]