IUBMB Enzyme Nomenclature

EC 1.16.8.1

Accepted name: cob(II)yrinic acid a,c-diamide reductase

Reaction: 2 cob(I)yrinic acid a,c-diamide + FMN + 2 H+ = 2 cob(II)yrinic acid a,c-diamide + FMNH2

For diagram click here.

Systematic name: cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase

Comments: This enzyme also catalyses the reduction of cob(II)yric acid, cob(II)inamide, cob(II)inamide phosphate, GDP-cob(II)inamide and cob(II)alamin although cob(II)yrinic acid a,c-diamide is thought to be the physiological substrate [1]. Also uses FAD and NADH but not NADPH.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 145539-93-1

References:

1. Blanche F., Maton, L., Debussche, L. and Thibaut, D. Purification and characterization of cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans. J. Bacteriol. 174 (1992) 7452-7454. [PMID: 1429467]

2. Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. The biosynthesis of adenosylcobalamin (vitamin B12). Nat. Prod. Rep. 19 (2002) 390-412. [PMID: 12195810]

[EC 1.16.8.1 created 2004]


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