IUBMB Enzyme Nomenclature


Accepted name: ribonucleoside-triphosphate reductase

Reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin

Other name(s): ribonucleotide reductase; 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase

Systematic name: 2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase

Comments: Requires a cobamide coenzyme and ATP.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9068-66-0


1. Blakley, R.L. Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii. J. Biol. Chem. 240 (1965) 2173-2180.

2. Goulian, M. and Beck, W.S. Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii. J. Biol. Chem. 241 (1966) 4233-4242. [PMID: 5924645]

3. Lammers, M. and Follmann, H. The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation. Struct. Bonding 54 (1983) 27-91.

[EC created 1972]

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