IUBMB Enzyme Nomenclature

EC 1.17.99.2

Accepted name: ethylbenzene hydroxylase

Reaction: ethylbenzene + H2O + acceptor = (S)-1-phenylethanol + reduced acceptor

For diagram click here.

Other names: ethylbenzene dehydrogenase; ethylbenzene:(acceptor) oxidoreductase

Systematic name: ethylbenzene:acceptor oxidoreductase

Comments: Involved in the anaerobic catabolism of ethylbenzene by denitrifying bacteria. Ethylbenzene is the preferred substrate; the enzyme from some strains oxidizes propylbenzene, 1-ethyl-4-fluorobenzene, 3-methylpent-2-ene and ethylidenecyclohexane. Toluene is not oxidized. p-Benzoquinone or ferrocenium can act as electron acceptor. Contains molybdopterin, [4Fe-4S] clusters and heme b.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 372947-56-3

References:

1. Kniemeyer, O. and Heider, J. Ethylbenzene dehydrogenase, a novel hydrocarbon-oxidising molybdenum/iron-sulfur/heme enzyme. J. Biol. Chem. 276 (2001) 21381-21386. [PMID: 11294876]

2. Johnson, H.A., Pelletier, D.A. and Spormann, A.M. Isolation and characterisation of anaerobic ethylbenzene dehydrogenase, a novel Mo-Fe-S enzyme. J. Bacteriol. 183 (2001) 4536-4542. [PMID: 11443088]

[EC 1.17.99.2 created 2001]


Return to EC 1.17.99 home page
Return to EC 1.17 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page