IUBMB Enzyme Nomenclature


Accepted name: adrenodoxin-NADP+ reductase

Reaction: 2 reduced adrenodoxin + NADP+ + H+ = 2 oxidized adrenodoxin + NADPH

Other name(s): adrenodoxin reductase; nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase; AdR; NADPH:adrenal ferredoxin oxidoreductase; NADPH-adrenodoxin reductase

Systematic name: reduced adrenodoxin:NADP+ oxidoreductase

Comments: A flavoprotein (FAD). The enzyme, which transfers electrons from NADPH to adrenodoxin molecules, is the first component of the mitochondrial cytochrome P-450 electron transfer systems, and is involved in the biosynthesis of all steroid hormones.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Omura, T., Sanders, E., Estabrook, R.W., Cooper, D.Y. and Rosenthal, O. Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase. Arch. Biochem. Biophys. 117 (1966) 660-673.

2. Chu, J.W. and Kimura, T. Studies on adrenal steroid hydroxylases. Molecular and catalytic properties of adrenodoxin reductase (a flavoprotein). J. Biol. Chem. 248 (1973) 2089-2094. [PMID: 4144106]

3. Sugiyama, T. and Yamano, T. Purification and crystallization of NADPH-adrenodoxin reductase from bovine adrenocortical mitochondria. FEBS Lett. 52 (1975) 145-148. [PMID: 235468]

4. Hanukoglu, I. and Jefcoate, C.R. Mitochondrial cytochrome P-450scc. Mechanism of electron transport by adrenodoxin. J. Biol. Chem. 255 (1980) 3057-3061. [PMID: 6766943]

5. Hanukoglu, I. and Hanukoglu, Z. Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation. Eur. J. Biochem. 157 (1986) 27-31. [PMID: 3011431]

6. Hanukoglu, I. and Gutfinger, T. cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases. Eur. J. Biochem. 180 (1989) 479-484. [PMID: 2924777]

7. Ziegler, G.A., Vonrhein, C., Hanukoglu, I. and Schulz, G.E. The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis. J. Mol. Biol. 289 (1999) 981-990. [PMID: 10369776]

[EC created 1965 as EC, transferred 1972 as EC, transferred 1978 to EC, part transferred 2012 to, modified 2016]

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