IUBMB Enzyme Nomenclature


Accepted name: 2-oxoaldehyde dehydrogenase (NAD)

Reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo carboxylate + NADH + H+

Other name(s): α-ketoaldehyde dehydrogenase; methylglyoxal dehydrogenase; NAD-linked α-ketoaldehyde dehydrogenase; 2-ketoaldehyde dehydrogenase; NAD-dependent α-ketoaldehyde dehydrogenase

Systematic name: 2-oxoaldehyde:NAD+ 2-oxidoreductase

Comments: Not identical with EC 2-oxoaldehyde dehydrogenase (NADP+).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37250-91-2


1. Monder, C. α-Keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate. J. Biol. Chem. 242 (1967) 4603-4609. [PMID: 4383524]

2. Ray, M. and Ray, S. On the interaction of nucleotides and glycolytic intermediates with NAD-linked α-ketoaldehyde dehydrogenase. J. Biol. Chem. 257 (1982) 10571-10574. [PMID: 7107626]

3. Ray, S. and Ray, M. Purification and characterization of NAD and NADP-linked α-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate. J. Biol. Chem. 257 (1982) 10566-10570. [PMID: 7107625]

[EC created 1972, modified 1986]

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