IUBMB Enzyme Nomenclature


Accepted name: succinate-semialdehyde dehydrogenase (NAD+)

Reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + 2 H+

For diagram of reaction click here.

Other name(s): succinate semialdehyde dehydrogenase (NAD+); succinic semialdehyde dehydrogenase (NAD+); succinyl semialdehyde dehydrogenase (NAD+); succinate semialdehyde:NAD+ oxidoreductase

Systematic name: succinate-semialdehyde:NAD+ oxidoreductase

Comments: This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC [succinate-semialdehyde dehydrogenase (NADP+)], and EC [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9028-95-9


1. Albers, R.W. and Koval, G.J. Succinic semialdehyde dehydrogenase : purification and properties of the enzyme from monkey brain. Biochim. Biophys. Acta 52 (1961) 29-35. [PMID: 13860092]

2. Ryzlak, M.T. and Pietruszko, R. Human brain "high Km" aldehyde dehydrogenase: purification, characterization, and identification as NAD+-dependent succinic semialdehyde dehydrogenase. Arch. Biochem. Biophys. 266 (1988) 386-396. [PMID: 3190233]

3. Busch, K.B. and Fromm, H. Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides. Plant Physiol. 121 (1999) 589-597. [PMID: 10517851]

[EC created 1972, modified 2010]

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