IUBMB Enzyme Nomenclature

EC 1.2.1.25

Accepted name: 2-oxoisovalerate dehydrogenase (acylating)

Reaction: 3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH

Other name(s): 2-oxoisovalerate dehydrogenase; α-ketoisovalerate dehydrogenase

Systematic name: 3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)

Comments: Also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxopentanoate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37211-61-3

References:

1. Namba, Y., Yoshizawa, K., Ejima, A., Hayashi, T. and Kaneda, T. Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain α-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis. J. Biol. Chem. 244 (1969) 4437-4447. [PMID: 4308861]

[EC 1.2.1.25 created 1972]


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