Reaction: (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-al + NAD+ + H2O = (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate + NADH + 2 H+
For diagram click here.
Other name(s): cholestanetriol-26-al 26-dehydrogenase; 3α,7α,12α-trihydroxy-5β-cholestan-26-al dehydrogenase; trihydroxydeoxycoprostanal dehydrogenase; THAL-NAD oxidoreductase; 3α,7α,12α-trihydroxy-5β-cholestan-26-al:NAD+ 26-oxidoreductase
Systematic name: (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-al:NAD+ 26-oxidoreductase
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 62213-58-5
References:
1. Masui, T., Herman, R. and Staple, E. The oxidation of 5β-cholestane-3α,7α,12α-26-tetraol to 5β-cholestane-3α,7α,12α-triol-26-oic acid via 5β-cholestane-3α,7α,12α-triol-26-al by rat liver. Biochim. Biophys. Acta 117 (1966) 266-268. [PMID: 5914340]