IUBMB Enzyme Nomenclature


Accepted name: 2-oxoaldehyde dehydrogenase (NADP+)

Reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo carboxylate + NADPH + H+

Other name(s): α-ketoaldehyde dehydrogenase; methylglyoxal dehydrogenase; NADP-linked α-ketoaldehyde dehydrogenase; 2-ketoaldehyde dehydrogenase; NADP-dependent α-ketoaldehyde dehydrogenase; 2-oxoaldehyde dehydrogenase (NADP)

Systematic name: 2-oxoaldehyde:NADP+ 2-oxidoreductase

Comments: Not identical with EC 2-oxoaldehyde dehydrogenase (NAD+).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 83588-97-0 and 97162-76-0


1. Ray, M. and Ray, S. On the interaction of nucleotides and glycolytic intermediates with NAD-linked α-ketoaldehyde dehydrogenase. J. Biol. Chem. 257 (1982) 10571-10574. [PMID: 7107626]

2. Ray, S. and Ray, M. Purification and characterization of NAD and NADP-linked α-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate. J. Biol. Chem. 257 (1982) 10566-10570. [PMID: 7107625]

[EC created 1986]

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