Reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo carboxylate + NADPH + H+
Other name(s): α-ketoaldehyde dehydrogenase; methylglyoxal dehydrogenase; NADP-linked α-ketoaldehyde dehydrogenase; 2-ketoaldehyde dehydrogenase; NADP-dependent α-ketoaldehyde dehydrogenase; 2-oxoaldehyde dehydrogenase (NADP)
Systematic name: 2-oxoaldehyde:NADP+ 2-oxidoreductase
Comments: Not identical with EC 188.8.131.52 2-oxoaldehyde dehydrogenase (NAD+).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 83588-97-0 and 97162-76-0
1. Ray, M. and Ray, S. On the interaction of nucleotides and glycolytic intermediates with NAD-linked α-ketoaldehyde dehydrogenase. J. Biol. Chem. 257 (1982) 10571-10574. [PMID: 7107626]
2. Ray, S. and Ray, M. Purification and characterization of NAD and NADP-linked α-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate. J. Biol. Chem. 257 (1982) 10566-10570. [PMID: 7107625]