IUBMB Enzyme Nomenclature


Accepted name: phenylglyoxylate dehydrogenase (acylating)

Reaction: phenylglyoxylate + NAD+ + CoA = benzoyl-S-CoA + CO2 + NADH

Glossary: thiamine diphosphate

Systematic name: phenylglyoxylate:NAD+ oxidoreductase

Comments: requires thiamine diphosphate as cofactor. The enzyme from the denitrifying bacterium Azoarcus evansii is specific for phenylglyoxylate. 2-Oxoisovalerate is oxidized at 15% of the rate for phenylglyoxylate. Also reduces viologen dyes. Contains iron-sulfur centres and FAD.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 205510-78-7


1. Hirsch, W., Schägger, H. and Fuchs, G. Phenylglyoxylate:NAD+ oxidoreductase (CoA benzoylating), a new enzyme of anaerobic phenylalanine metabolism in the denitrifying bacterium Axoarcus evansii. Eur. J. Biochem. 251 (1998) 907-915. [PMID: 9490067]

[EC created 1999]

Return to EC 1.2.1 home page
Return to EC 1.2 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page