IUBMB Enzyme Nomenclature


Accepted name: 4-hydroxymuconic-semialdehyde dehydrogenase

Reaction: 4-hydroxymuconic semialdehyde + NAD+ + H2O = maleylacetate + NADH + 2 H+

For diagram of reaction click here.

Systematic name: 4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase

Comments: Involved in the 4-nitrophenol degradation pathway.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number:


1. Spain, J.C. and Gibson, D.T. Pathway for bioremediation of p-nitrophenol in a Moraxella sp. Appl. Environ. Microbiol. 57 (1991) 812-819.

[EC created 2000]

Return to EC 1.2.1 home page
Return to EC 1.2 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page