IUBMB Enzyme Nomenclature


Accepted name: succinate-semialdehyde dehydrogenase (NADP+)

Reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+

For diagram of reaction click here.

Other name(s): succinic semialdehyde dehydrogenase (NADP+); succinyl semialdehyde dehydrogenase (NADP+); succinate semialdehyde:NADP+ oxidoreductase; NADP-dependent succinate-semialdehyde dehydrogenase; GabD

Systematic name: succinate-semialdehyde:NADP+ oxidoreductase

Comments: This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC [succinate-semialdehyde dehydrogenase (NAD+)], and EC [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+. The enzyme from Escherichia coli is 20-fold more active with NADP+ than NAD+ [2].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Bartsch, K., von Johnn-Marteville, A. and Schulz, A. Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD). J. Bacteriol. 172 (1990) 7035-7042. [PMID: 2254272]

2. Jaeger, M., Rothacker, B. and Ilg, T. Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases. Biochem. Biophys. Res. Commun. 372 (2008) 400-406. [PMID: 18474219]

[EC created 2010]

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