IUBMB Enzyme Nomenclature

EC 1.2.99.2

Accepted name: carbon-monoxide dehydrogenase (acceptor)

Reaction: CO + H2O + A = CO2 + AH2

Other name(s): anaerobic carbon monoxide dehydrogenase; carbon monoxide oxygenase; carbon-monoxide dehydrogenase; carbon-monoxide:(acceptor) oxidoreductase

Systematic name: carbon-monoxide:acceptor oxidoreductase

Comments: Contains a [Ni3Fe-4S] cluster and [4Fe-4S] clusters. It uses many electron acceptors, including ferredoxin, methyl viologen and benzyl viologen and flavins, but not pyridine nucleotides. Forms part of a membrane-bound multienzyme complex with EC 1.12.99.6, hydrogenase (acceptor), which catalyses the overall reaction: CO + H2O = CO2 + H2.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 64972-88-9

References:

1. Bonam, D. and Ludden, P.W. Purification and characterization of carbon monoxide dehydrogenase, a nickel, zinc, iron-sulfur protein, from Rhodospirillum rubrum. J. Biol. Chem. 262 (1987) 2980-2987. [PMID: 3029096]

2. Diekert, G. and Ritter, M. Purification of the nickel protein carbon monoxide dehydrogenase of Clostridium thermoaceticum. FEBS Lett. 151 (1983) 41-44. [PMID: 6687458]

3. Drennan, C.L., Heo, J., Sintchak, M.D., Schreiter, E. and Ludden, P.W. Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase. Proc. Natl. Acad. Sci. USA 98 (2001) 11973-11978. [PMID: 11593006]

4. Dobbek, H., Svetlitchnyi, V., Gremer, L., Huber, R. and Meyer, O. Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster. Science 293 (2001) 1281-1285. [PMID: 11509720]

[EC 1.2.99.2 created 1982, modified 1990, modified 2003]


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