Reaction: methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O
For diagram click here.
Glossary: methylarsonite = methylarsonous acid
cacodylic acid = dimethylarsinic acid
Other name(s): MMA(V) reductase; gluthathione:methylarsonate oxidoreductase
Systematic name: methylarsonate:glutathione oxidoreductase
Comments: The product, Me-As(OH)2, is biologically methylated by EC 126.96.36.199, arsenite methyltransferase, to form cacodylic acid.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 254889-62-8
1. Zakharyan, R.A. and Aposhian, H.V. Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase. Chem. Res. Toxicol. 12 (1999) 1278-1283. [PMID: 10604879]