IUBMB Enzyme Nomenclature

EC 1.20.4.2

Accepted name: methylarsonate reductase

Reaction: methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O

For diagram click here.

Other name(s): MMA(V) reductase

Systematic name: gluthathione:methylarsonate oxidoreductase

Comments: The product, Me-As(OH)2 (methylarsonous acid), is biologically methylated by EC 2.1.1.137, arsenite methyltransferase, to form cacodylic acid (dimethylarsinic acid).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 254889-62-8

References:

1. Zakharyan, R.A. and Aposhian, H.V. Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase. Chem. Res. Toxicol. 12 (1999) 1278-1283. [PMID: 10604879]

[EC 1.20.4.2 created 2000 as EC 1.97.1.7, transferred 2001 to EC 1.20.4.2, modified 2003]


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