Reaction: an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
Other name(s): acyl-ACP dehydrogenase; reductase, enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate); NADPH 2-enoyl Co A reductase; enoyl acyl-carrier-protein reductase; enoyl-ACP reductase; enoyl-[acyl-carrier-protein] reductase (NADPH2, B-specific)
Systematic name: acyl-[acyl-carrier protein]:NADP+ oxidoreductase (B-specific)
Comments: One of the activities of EC 2.3.1.86, fatty-acyl-CoA synthase, an enzyme found in yeasts (Ascomycota and the Basidiomycota). Catalyses the reduction of enoyl-acyl-[acyl-carrier protein] derivatives of carbon chain length from 4 to 16. The yeast enzyme is B-specific with respect to NADP+. cf. EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) and EC 1.3.1.9, enoyl-[acyl-carrier-protein] reductase (NADH).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37251-09-5
References:
1. Saito, K., Kawaguchi, A., Okuda, S., Seyama, Y. and Yamakawa, T. Incorporation of hydrogen atoms from deuterated water and stereospecifically deuterium-labeled nicotinamide nucleotides into fatty acids with the Escherichia coli fatty acid synthetase system. Biochim. Biophys. Acta 618 (1980) 202-213. [PMID: 6990992]
2. Seyama, T., Kasama, T., Yamakawa, T., Kawaguchi, A., Saito, K. and Okuda, S. Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase. J. Biochem. (Tokyo) 82 (1977) 1325-1329. [PMID: 338601]
3. Weeks, G. and Wakil, S.J. Studies on the mechanism of fatty acid synthesis. 18. Preparation and general properties of the enoyl acyl carrier protein reductases from Escherichia coli. J. Biol. Chem. 243 (1968) 1180-1189. [PMID: 4384650]