Reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH
For diagram click here.
Other name(s): hydroxyphenylpyruvate synthase; chorismate mutaseprephenate dehydrogenase
Systematic name: prephenate:NAD+ oxidoreductase (decarboxylating)
Comments: This enzyme in the enteric bacteria also possesses chorismate mutase activity (EC 22.214.171.124 chorismate mutase) and converts chorismate into prephenate.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9044-92-2
1. Koch, G.L.E., Shaw, D.C. and Gibson, F. Tyrosine biosynthesis in Aerobacter aerogenes. Purification and properties of chorismate mutase-prephenate dehydrogenase. Biochim. Biophys. Acta 212 (1970) 375-386. [PMID: 5456988]