IUBMB Enzyme Nomenclature


Accepted name: 7-dehydrocholesterol reductase

Reaction: cholesterol + NADP+ = cholesta-5,7-dien-3β-ol + NADPH + H+

For diagram of reaction click here.

Other name(s): DAF-36 (gene name); DHCR7 (gene name); 7-DHC reductase; 7-dehydrocholesterol dehydrogenase/cholesterol oxidase; Δ7-sterol reductase

Systematic name: cholesterol:NADP+ Δ7-oxidoreductase

Comments: The enzyme is part of the cholesterol biosynthesis pathway.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9080-21-1


1. Dempsey, M.E., Seaton, J.D., Schroepfer, G.J. and Trockman, R.W. The intermediary role of Δ5,7-cholestadien-3β-ol in cholesterol biosynthesis. J. Biol. Chem. 239 (1964) 1381-1387. [PMID: 14189869]

2. Moebius, F.F., Fitzky, B.U., Lee, J.N., Paik, Y.K. and Glossmann, H. Molecular cloning and expression of the human Δ7-sterol reductase. Proc. Natl. Acad. Sci. USA 95 (1998) 1899-1902. [PMID: 9465114]

[EC created 1972, modified 2013]

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