IUBMB Enzyme Nomenclature


Accepted name: 2,4-dienoyl-CoA reductase (NADPH)

Reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+

Other name(s): 4-enoyl-CoA reductase (NADPH2); 4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase; 4-enoyl-CoA reductase; 2,4-dienoyl-CoA reductase (NADPH2)

Systematic name: trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase

Comments: Best substrates for reduction contain a 2,4-diene structure with a chain-length of 8 or 10

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 82869-38-3


1. Dommes, V., Luster, W., Cvetanovic, M. and Kunau, W.-H. Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli. Eur. J. Biochem. 125 (1982) 335-341. [PMID: 6749495]

2. Kunau, W.-H. and Dommes, P. Degradation of unsaturated fatty acids. Identification of intermediates in the degradation of cis-4-decenoly-CoA by extracts of beef-liver mitochondria. Eur. J. Biochem. 91 (1978) 533-544. [PMID: 729581]

[EC created 1984, modified 1986]

Return to EC 1.3.1 home page
Return to EC 1.3 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page