Reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD+ = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + NADH + H+
Other name(s): oleate desaturase; linoleate synthase; oleoyl-CoA desaturase; oleoylphosphatidylcholine desaturase
Systematic name: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ Δ12-oxidoreductase
Comments: Also desaturates phosphatidylcholine containing the oleoyl group on O-2 of the glycerol residue.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 72536-70-0
References:
1. Pugh, E.L. and Kates, M. Characterization of a membrane-bound phospholipid desaturase system of Candida lipolytica. Biochim. Biophys. Acta 380 (1975) 442-453. [PMID: 166662]
2. Slack, C.R., Roughan, P.G. and Browse, J. Evidence for an oleoyl phosphatidylcholine desaturase in microsomal preparations from cotyledons of safflower (Carthamus tinctorius) seed. Biochem. J. 179 (1979) 649-656. [PMID: 475773]
3. Stymne, S. and Åppelqvist, L.-A. The biosynthesis of linoleate from oleoyl-CoA via oleoyl-phosphatidylcholine in microsomes of developing safflower seeds. Eur. J. Biochem. 90 (1978) 223-229.