Reaction: 4,5α-dihydrocortisone + NADP+ = cortisone + NADPH + H+
Other name(s): cortisone Δ4-5α-reductase; microsomal steroid reductase (5α); Δ4-3-ketosteroid reductase (5α); Δ4-3-oxosteroid-5α-reductase; NADPH:Δ4-3-oxosteroid-5α-oxidoreductase; Δ4-5α-reductase
Systematic name: 4,5α-dihydrocortisone:NADP+ Δ4-oxidoreductase
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 9029-09-8
References:
1. McGuire, J.S., Hollis, V.W. and Tomkins, G.M. Some characteristics of the microsomal steroid reductases (5α) of rat liver. J. Biol. Chem. 235 (1960) 3112-3117.