IUBMB Enzyme Nomenclature


Accepted name: 2'-hydroxyisoflavone reductase

Reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+

For diagram click here.

Other name(s): NADPH:2'-hydroxyisoflavone oxidoreductase; isoflavone reductase; 2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase

Systematic name: vestitone:NADP+ oxidoreductase

Comments: In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an isoflavanone; 2'-hydroxypseudobaptigenin also acts. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 128449-69-4


1. Tiemann, K., Hinderer, W. and Barz, W. Isolation of NADPH:isoflavone oxidoreductase, a new enzyme of pterocarpan biosynthesis in cell suspensions of Cicer arietinum. FEBS Lett. 213 (1987) 324-328.

[EC created 1990]

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