IUBMB Enzyme Nomenclature

EC 1.3.1.70

Accepted name: Δ14-sterol reductase

Reaction: 4,4-dimethyl-5α-cholesta-8,24-dien-3β-ol + NADP+ = 4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol + NADPH + H+

For diagram click here.

Systematic name: 4,4-dimethyl-5α-cholesta-8,24-dien-3β-ol:NADP+ Δ14-oxidoreductase

Comments: This enzyme acts on a range of steroids with a 14(15)-double bond.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 69403-07-2

References:

1. Bottema, C.K. and Parks, L.W. Δ14-Sterol reductase in Saccharomyces cerevisiae. Biochim. Biophys. Acta 531 (1978) 301-307. [PMID: 32908]

2. Paik, Y.K., Trzaskos, J.M., Shafice, A. and Gaylor, J.L. Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent Δ8,14-steroid 14-reductase. J. Biol. Chem. 259 (1984) 13413-13423. [PMID: 6444198]

[EC 1.3.1.70 created 2001]


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