IUBMB Enzyme Nomenclature

EC 1.3.1.77

Accepted name: anthocyanidin reductase

Reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+

For diagram click here.

Other name(s): AtANR; MtANR

Systematic name: flavan-3-ol:NAD(P)+ oxidoreductase

Comments: Forms 2,3-cis-flavan-3-ols. The isomeric 2,3-trans-flavan-3-ols are formed from flavan-3,4-diols by EC 1.17.1.3 leucoanthocyanidin reductase. While the enzyme from the legume Medicago truncatula (MtANR) uses both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 93389-48-1

References:

1. Xie, D.Y., Sharma, S.B., Paiva, N.L., Ferreira, D. and Dixon, R.A. Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis. Science 299 (2003) 396-399. [PMID: 12532018]

2. Xie, D.Y., Sharma, S.B. and Dixon, R.A. Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana. Arch. Biochem. Biophys. 422 (2004) 91-102. [PMID: 14725861]

[EC 1.3.1.77 created 2004]


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