IUBMB Enzyme Nomenclature

EC 1.3.99.12

Accepted name: 2-methylacyl-CoA dehydrogenase

Reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor

Other name(s): branched-chain acyl-CoA dehydrogenase; 2-methyl branched chain acyl-CoA dehydrogenase; 2-methylbutanoyl-CoA:(acceptor) oxidoreductase

Systematic name: 2-methylbutanoyl-CoA:acceptor oxidoreductase

Comments: Also oxidizes 2-methylpropanoyl-CoA. Not identical with EC 1.3.8.1 (butyryl-CoA dehydrogenase), EC 1.3.8.7 (medium-chain acyl-CoA dehydrogenase), EC 1.3.8.8 (long-chain acyl-CoA dehydrogenase), EC 1.3.8.9 (very-long-chain acyl-CoA dehydrogenase) or EC 1.3.99.10 (isovaleryl-CoA dehydrogenase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 85130-32-1

References:

1. Ikeda, Y., Dabrowski, C. and Tanaka, K. Separation and properties of five distinct acyl-CoA dehydrogenases from rat liver mitochondria. Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase. J. Biol. Chem. 258 (1983) 1066-1076. [PMID: 6401712]

[EC 1.3.99.12 created 1986]


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