Reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+
Other name(s): L-leucine dehydrogenase; L-leucine:NAD+ oxidoreductase, deaminating; LeuDH
Systematic name: L-leucine:NAD+ oxidoreductase (deaminating)
Comments: Also acts on isoleucine, valine, norvaline and norleucine.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9082-71-7
1. Sanwal, B.D. and Zink, M.W. L-Leucine dehydrogenase of Bacillus cereus. Arch. Biochem. Biophys. 94 (1961) 430-435.
2. Zink, M.W. and Sanwal, B.D. The distribution and substrate specificity of L-leucine dehydrogenase. Arch. Biochem. Biophys. 99 (1962) 72-77.