Reaction: L-aspartate + O2 = iminosuccinate + H2O2
For diagram of reaction click here.
Other name(s): NadB; Laspo; AO
Systematic name: L-aspartate:oxygen oxidoreductase (deaminating)
Comments: A flavoprotein (FAD). L-Aspartate oxidase catalyses the first step in the de novo biosynthesis of NAD+ in some bacteria. O2 can be replaced by fumarate as electron acceptor, yielding succinate . The ability of the enzyme to use both O2 and fumarate in cofactor reoxidation enables it to function under both aerobic and anaerobic conditions . Iminosuccinate can either be hydrolysed to form oxaloacetate and NH3 or can be used by EC 18.104.22.168, quinolinate synthase, in the production of quinolinate. The enzyme is a member of the succinate dehydrogenase/fumarate-reductase family of enzymes .
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 69106-47-4
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