IUBMB Enzyme Nomenclature

EC 1.4.3.20

Accepted name: L-lysine 6-oxidase

Reaction: L-lysine + O2 + H2O = (S)-2-amino-6-oxohexanoate + H2O2 + NH3

Glossary: (S)-2-amino-6-oxohexanoate = L-2-aminoadipate 6-semialdehyde = L-allysine

Other name(s): L-lysine-ε-oxidase; Lod; LodA; marinocine

Systematic name: L-lysine:oxygen 6-oxidoreductase (deaminating)

Comments: Differs from EC 1.4.3.13, protein-lysine 6-oxidase, by using free L-lysine rather than the protein-bound form. 2-N-Acetyl-L-lysine is also a substrate, but 6-N-acetyl-L-lysine, which has an acetyl group at position 6, is not a substrate. Also acts on L-ornithine, D-lysine and 4-hydroxy-L-lysine, but more slowly. The amines cadaverine and putrescine are not substrates [2].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 1116448-48-6

References:

1. Lucas-Elío, P., Gómez, D., Solano, F. and Sanchez-Amat, A. The antimicrobial activity of marinocine, synthesized by Marinomonas mediterranea, is due to hydrogen peroxide generated by its lysine oxidase activity. J. Bacteriol. 188 (2006) 2493-2501. [PMID: 16547036]

2. Gómez, D., Lucas-Elío, P., Sanchez-Amat, A. and Solano, F. A novel type of lysine oxidase: L-lysine-ε-oxidase. Biochim. Biophys. Acta 1764 (2006) 1577-1585. [PMID: 17030025]

[EC 1.4.3.20 created 2006]


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