Reaction: a D-amino acid + H2O + a quinone = a 2-oxo carboxylate + NH3 + a quinol
Other name(s): DadA
Systematic name: D-amino acid:quinone oxidoreductase (deaminating)
Comments: An iron-sulfur flavoprotein (FAD). The enzyme from the bacterium Helicobacter pylori is highly specific for D-proline, while the enzyme from the bacterium Escherichia coli B is most active with D-alanine, D-phenylalanine and D-methionine. This enzyme may be the same as EC 18.104.22.168.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Olsiewski, P.J., Kaczorowski, G.J. and Walsh, C. Purification and properties of D-amino acid dehydrogenase, an inducible membrane-bound iron-sulfur flavoenzyme from Escherichia coli B. J. Biol. Chem. 255 (1980) 4487-4494. [PMID: 6102989]
2. Tanigawa, M., Shinohara, T., Saito, M., Nishimura, K., Hasegawa, Y., Wakabayashi, S., Ishizuka, M. and Nagata, Y. D. Amino acid dehydrogenase from Helicobacter pylori NCTC 11637. Amino Acids 38 (2010) 247-255. [PMID: 19212808]