Reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+
Other name(s): δ1-pyrroline-2-carboxylate reductase
Systematic name: L-proline:NAD(P)+ 2-oxidoreductase
Comments: Reduces 1-pyrroline-2-carboxylate to L-proline and also 1,2-didehydropiperidine-2-carboxylate to L-pipecolate.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, CAS registry number: 9029-16-7
References:
1. Meister, A., Radhakrishnan, A.N. and Buckley, S.D. Enzymatic synthesis of L-pipecolic acid and L-proline. J. Biol. Chem. 229 (1957) 789-800.