IUBMB Enzyme Nomenclature

EC 1.5.1.17

Accepted name: alanopine dehydrogenase

Reaction: 2,2'-iminodipropanoate + NAD+ + H2O = L-alanine + pyruvate + NADH + H+

Other name(s): ALPDH ; alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase; meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase; alanopine: NAD oxidoreductase; ADH; alanopine:NAD oxidoreductase

Systematic name: 2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)

Comments: In the reverse reaction, L-alanine can be replaced by L-cysteine, L-serine or L-threonine; glycine acts very slowly (cf. EC 1.5.1.22 strombine dehydrogenase).

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, CAS registry number: 71343-07-2

References:

1. Dando, P.R. Strombine [N-(carboxymethyl)-D-alanine] dehydrogenase and alanopine [meso-N-(1-carboxyethyl)-alanine dehydrogenase from the mussel Mytilus edulis L. Biochem. Soc. Trans. 9 (1981) 297-298.

2. Fields, J.H.A., Eng, A.K., Ramsden, W.D., Hochachka, P.W. and Weinstein, B. Alanopine and strombine are novel imino acids produced by a dehydrogenase found in the adductor muscle of the oyster, Crassostrea gigas. Arch. Biochem. Biophys. 201 (1980) 110-114. [PMID: 6156653]

3. Fields, J.H.A. and Hochachka, P.W. Purification and properties of alanopine dehydrogenase from the adductor muscle of the oyster, Crassostrea gigas (Mollusca, Bivalvia). Eur. J. Biochem. 114 (1981) 615-621. [PMID: 7238503]

[EC 1.5.1.17 created 1983, modified 1986]


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