IUBMB Enzyme Nomenclature


Accepted name: flavin reductase (NADH)

Reaction: reduced flavin + NAD+ = flavin + NADH + H+

Other name(s): NADH-dependent flavin reductase; flavin:NADH oxidoreductase

Systematic name: flavin:NAD+ oxidoreductase

Comments: The enzyme from Escherichia coli W catalyses the reduction of free flavins by NADH. The enzyme has similar affinity to FAD, FMN and riboflavin. Activity with NADPH is more than 2 orders of magnitude lower than activity with NADH.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Galan, B., Diaz, E., Prieto, M.A. and Garcia, J.L. Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily. J. Bacteriol. 182 (2000) 627-636. [PMID: 10633095]

[EC created 2011]

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