Reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+
For diagram of reaction click here.
Other name(s): FRG
Systematic name: FMNH2:NAD(P)+ oxidoreductase
Comments: Contains FMN. The enzyme can utilize NADH and NADPH with similar reaction rates. Different from EC 18.104.22.168, FMN reductase (NADH) and EC 22.214.171.124, FMN reductase (NADPH). The luminescent bacterium Vibrio harveyi possesses all three enzymes . Also reduces riboflavin and FAD, but more slowly.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:
1. Watanabe, H. and Hastings, J.W. Specificities and properties of three reduced pyridine nucleotide-flavin mononucleotide reductases coupling to bacterial luciferase. Mol. Cell. Biochem. 44 (1982) 181-187. [PMID: 6981058]