IUBMB Enzyme Nomenclature


Accepted name: 8-hydroxy-5-deazaflavin:NADPH oxidoreductase

Reaction: reduced coenzyme F420 + NADP+ = oxidized coenzyme F420 + NADPH + H+

For diagram of reaction click here.

Other name(s): 8-OH-5dFl:NADPH oxidoreductase

Systematic name: reduced coenzyme F420:NADP+ oxidoreductase

Comments: The enzyme has an absolute requirement for both the 5-deazaflavin structure and the presence of an 8-hydroxy group in the substrate [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Eker, A.P., Hessels, J.K. and Meerwaldt, R. Characterization of an 8-hydroxy-5-deazaflavin:NADPH oxidoreductase from Streptomyces griseus. Biochim. Biophys. Acta 990 (1989) 80-86. [PMID: 2492438]

[EC created 2011]

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