IUBMB Enzyme Nomenclature



Accepted name: polyamine oxidase (propane-1,3-diamine-forming)

Reaction: spermidine + O2 + H2O = propane-1,3-diamine + 4-aminobutanal + H2O2

Other name(s): MPAO; maize PAO

Systematic name: spermidine:oxygen oxidoreductase (propane-1,3-diamine-forming)

Comments: As the products of the reaction cannot be converted directly to other polyamines, this class of polyamine oxidases is considered to be involved in the terminal catabolism of polyamines [1]. This enzyme less efficiently catalyses the oxidation of N1-acetylspermine and spermine. A flavoprotein (FAD). Differs in specificity from EC (N1-acetylpolyamine oxidase), EC [N8-acetylspermidine oxidase (propane-1,3-diamine-forming)], EC (spermine oxidase) and EC (non-specific polyamine oxidase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Tavladoraki, P., Schinina, M.E., Cecconi, F., Di Agostino, S., Manera, F., Rea, G., Mariottini, P., Federico, R. and Angelini, R. Maize polyamine oxidase: primary structure from protein and cDNA sequencing. FEBS Lett. 426 (1998) 62-66. [PMID: 9598979]

2. Federico, R., Ercolini, L., Laurenzi, M., Angelini, R. Oxidation of acetylpolyamines by maize polyamine oxidase. Phytochemistry 43 (1996) 339-341.

[EC created 2009]

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