Reaction: a pyrimidodiazepine + glutathione disulfide + H2O = 6-pyruvoyltetrahydropterin + 2 glutathione
Other name(s): PDA synthase; pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening, cyclizing)
Systematic name: pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
Comments: In the reverse direction of reaction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine involved is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 93586-06-2
References:
1. Wiederrecht, G.J. and Brown, G.M. Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins. J. Biol. Chem. 259 (1984) 14121-14127.