Reaction: L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol
Other name(s): L-proline dehydrogenase; L-proline:(acceptor) oxidoreductase
Systematic name: L-proline:quinone oxidoreductase
Comments: A flavoprotein (FAD). The electrons from L-proline are transferred to the FAD cofactor, and from there to a quinone acceptor . In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 18.104.22.168, L-glutamate γ-semialdehyde dehydrogenase. Both activities are carried out by the same enzyme in enterobacteria.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9050-70-8
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