IUBMB Enzyme Nomenclature


Accepted name: methylglutamate dehydrogenase

Reaction: N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor

Other name(s): N-methylglutamate dehydrogenase; N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)

Systematic name: N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)

Comments: A number of N-methyl-substituted amino acids can act as donor; 2,6-dichloroindophenol is the best acceptor.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37217-26-8


1. Hersh, L.B., Stark, M.J., Worthen, S. and Fiero, M.K. N-Methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme. Arch. Biochem. Biophys. 150 (1972) 219-226. [PMID: 5028076]

[EC created 1976]

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