Reaction: NADPH + NAD+ = NADP+ + NADH
Other name(s): pyridine nucleotide transhydrogenase; transhydrogenase; NAD(P) transhydrogenase; nicotinamide adenine dinucleotide (phosphate) transhydrogenase; NAD transhydrogenase; NADH transhydrogenase; nicotinamide nucleotide transhydrogenase; NADPH-NAD transhydrogenase; pyridine nucleotide transferase; NADPH-NAD oxidoreductase; NADH-NADP-transhydrogenase; NADPH:NAD+ transhydrogenase; H+-Thase; non-energy-linked transhydrogenase; NAD(P) transhydrogenase (B-specific)
Systematic name: NADPH:NAD+ oxidoreductase (B-specific)
Comments: The enzyme from Azotobacter vinelandii is a flavoprotein (FAD). It is B-specific with respect to both NAD+ and NADP+. Also acts on deamino coenzymes [cf. EC 1.6.1.2 NAD(P)+ transhydrogenase (AB-specific)].
Links to other databases: BRENDA, EXPASY, GTD, KEGG, CAS registry number: 9014-18-0 and 9072-60-0
References:
1. Humphrey, G.F. The distribution and properties of transhydrogenase from animal tissues. Biochem. J. 65 (1957) 546-550.
2. You, K.-S. Stereospecificity for nicotinamide nucleotides in enzymatic and chemical hydride transfer reactions. CRC Crit. Rev. Biochem. 17 (1985) 313-451. [PMID: 3157549]