IUBMB Enzyme Nomenclature


Accepted name: NAD(P)+ transhydrogenase (Re/Si-specific)

Reaction: NADPH + NAD+ = NADP+ + NADH

Other name(s): pyridine nucleotide transhydrogenase; transhydrogenase; NAD(P)+ transhydrogenase; nicotinamide adenine dinucleotide (phosphate) transhydrogenase; NAD+ transhydrogenase; NADH transhydrogenase; nicotinamide nucleotide transhydrogenase; NADPH-NAD+ transhydrogenase; pyridine nucleotide transferase; NADPH-NAD+ oxidoreductase; NADH-NADP+-transhydrogenase; NADPH:NAD+ transhydrogenase; H+-Thase; energy-linked transhydrogenase; NAD(P) transhydrogenase (AB-specific); NAD(P)+ transhydrogenase (AB-specific); NADPH:NAD+ oxidoreductase (AB-specific)

Systematic name: NADPH:NAD+ oxidoreductase (Re/Si-specific)

Comments: The enzyme from heart mitochondria is Re-specific with respect to NAD+ and Si-specific with respect to NADP+ [cf. EC NAD(P)+ transhydrogenase (Si-specific)].

Links to other databases: BRENDA, EXPASY, KEGG, PDB, CAS registry number: 9014-18-0, 9072-60-0


1. Fisher, R.R. and Earle, S.R. Membrane-bound pyridine dinucleotide transhydrogenases. In: Everse, J., Anderson, B. and You, K. (Eds), The Pyridine Nucleotide Coenzymes, The Pyridine Nucleotide Coenzymes, New York, 1982, pp. 279-324.

2. You, K.-S. Stereospecificity for nicotinamide nucleotides in enzymatic and chemical hydride transfer reactions. CRC Crit. Rev. Biochem. 17 (1985) 313-451. [PMID: 3157549]

[EC created 1986, modified 2013]

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