Reaction: NADPH + NAD+ = NADP+ + NADH
Other name(s): pyridine nucleotide transhydrogenase; transhydrogenase; NAD(P) transhydrogenase; nicotinamide adenine dinucleotide (phosphate) transhydrogenase; NAD transhydrogenase; NADH transhydrogenase; nicotinamide nucleotide transhydrogenase; NADPH-NAD transhydrogenase; pyridine nucleotide transferase; NADPH-NAD oxidoreductase; NADH-NADP-transhydrogenase; NADPH:NAD+ transhydrogenase; H+-Thase; energy-linked transhydrogenase; NAD(P) transhydrogenase (AB-specific)
Systematic name: NADPH:NAD+ oxidoreductase (AB-specific)
Comments: The enzyme from heart mitochondria is A-specific with respect to NAD+ and B-specific with respect to NADP+ [cf. EC 1.6.1.1 NAD(P)+ transhydrogenase (B-specific)].
Links to other databases: BRENDA, EXPASY, KEGG, PDB, CAS registry number: 9014-18-0 and 9072-60-0
References:
1. Fisher, R.R. and Earle, S.R. Membrane-bound pyridine dinucleotide transhydrogenases. In: Everse, J., Anderson, B. and You, K. (Eds.), The Pyridine Nucleotide Coenzymes, Academic Press, New York, 1982, p. 279-324.
2. You, K.-S. Stereospecificity for nicotinamide nucleotides in enzymatic and chemical hydride transfer reactions. CRC Crit. Rev. Biochem. 17 (1985) 313-451. [PMID: 3157549]