IUBMB Enzyme Nomenclature


Accepted name: cytochrome-b5 reductase

Reaction: NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5

Other name(s): cytochrome b5 reductase; dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase; reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase; NADH-ferricytochrome b5 oxidoreductase; NADH-cytochrome b5 reductase; NADH 5α-reductase ; NADH-cytochrome-b5 reductase

Systematic name: NADH:ferricytochrome-b5 oxidoreductase

Comments: A flavoprotein (FAD).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9032-25-1


1. Mahler, H.R., Raw, I., Molinari, R. and do Amaral, D.F. Studies of electron transport enzymes. II. Isolation and some properties of a cytochrome-specific reduced diphosphopyridine nucleotide dehydrogenase from pig liver. J. Biol. Chem. 233 (1958) 230-239.

2. Strittmatter, P. Microsomal cytochrome b5 and cytochrome b5 reductase. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 113-145.

3. Strittmatter, P. and Velick, S.F. The purification and properties of microsomal cytochrome reductase. J. Biol. Chem. 228 (1957) 785-799.

[EC created 1961]

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