Reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein
Other name(s): CPR; FAD-cytochrome c reductase; NADPcytochrome c reductase; NADPcytochrome reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase; NADPH:ferrihemoprotein oxidoreductase; NADPHcytochrome P-450 oxidoreductase; NADPHcytochrome c oxidoreductase; NADPHcytochrome c reductase; NADPHcytochrome p-450 reductase; NADPHferricytochrome c oxidoreductase; NADPHferrihemoprotein reductase; TPNH2 cytochrome c reductase; TPNH-cytochrome c reductase; aldehyde reductase (NADPH-dependent); cytochrome P-450 reductase; cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent); dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase; ferrihemoprotein P-450 reductase; reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase; reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)
Systematic name: NADPH:hemoprotein oxidoreductase
Comments: A flavoprotein (FMN, FAD) containing both FMN and FAD. The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction. The enzyme catalyses the reduction of the heme-thiolate-dependent monooxygenases, such as EC 220.127.116.11, unspecific monooxygenase and reduction of EC 18.104.22.168, heme oxygenase (decyclizing). It is part of the microsomal hydroxylating system. It also reduces cytochrome b5 and cytochrome c.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9023-03-4
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